STUDIES ON ANNELATED [1,4]BENZOTHIAZINES AND [1,5]BENZOTHIAZEPINES .5. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-2 ALKYLAMINO DERIVATIVES OF 4,5-DIHYDRO-S-TRIAZOLO[3,4-D]-1,5-BENZOTHIAZEPINE

被引：15

作者：

AMBROGI, V ^{[1
]}

GIAMPIETRI, A ^{[1
]}

GRANDOLINI, G ^{[1
]}

PERIOLI, L ^{[1
]}

RICCI, M ^{[1
]}

TUTTOBELLO, L ^{[1
]}

机构：

[1] UNIV PERUGIA,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,SEZ FARMACOL,I-06100 PERUGIA,ITALY

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 09期

关键词：

D O I：

10.1002/ardp.19923250909

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new series of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine has been accomplished starting from 2,3-dihydro-1,5-benzothiazepin-4(5H)ones and their 2-methyl and 2-aryl derivatives. - All the compounds were tested in vitro for their antimicrobial activity, but none of them showed remarkable activity. The tricyclic compounds 7a-j, 8a-j, 9a-j, 10a-j, and 11a-j were also screened for their CNS activity in mice and several of them showed interesting activity.

引用

页码：569 / 577

页数：9

共 50 条

[41] An efficient one-pot, three-component synthesis of novel [1,2,4]triazolo [4′,3′:1,5][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives and their molecular docking studies
Jilloju, Parameshwara Chary
Shyam, Perugu
Aravind, Seema
Vedula, Rajeswar Rao
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2024, 61 (10) : 1586 - 1596
[42] Crystal structure of 4,5-dihydro-7-amino-5-oxo-[1,2,4]-triazolo-[1,5-a]pyrimidine, C5H5N5O
Orgueira, H
Haj, MA
Salas, JM
Jensen, WP
Tiekink, ERT
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 1999, 214 (04): : 517 - 518
[43] NEW[G]-FUSED [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINES - SYNTHESIS OF PYRIDO[3,2-E] AND [4,3-E][1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE, PYRIMIDO[5,4-E][1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE AND [1,2,4]TRIAZOLO[1,5-C]PTERIDINE DERIVATIVES
DELGIUDICE, MR
BORIONI, A
MUSTAZZA, C
GATTA, F
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1994, 31 (06) : 1503 - 1507
[44] Reactions of tetrahydropyrido[4,5-d][1,2,4]triazolo[1,5-a]-pyrimidin-4-ones with activated alkynes. Synthesis of [1,2,4]triazolo[1',5':1,2]pyrimido[4,5-d]azocines
Voskressensky, L. G.
Borisova, T. N.
Ovcharov, M. V.
Sorokina, E. A.
Khrustalev, V. N.
Varlamov, A. V.
RUSSIAN CHEMICAL BULLETIN, 2012, 61 (08) : 1603 - 1608
[45] STUDIES ON GROUND AND EXCITED REACTIONS OF 2-METHYL-1,5-BENZOTHIAZEPINES .1. CHLORINATIONS OF 2-METHYL-1, 5-BENZOTHIAZEPIN-4(5H)-ONE AND NUCLEOPHILIC SUBSTITUTIONS OF 2-METHYL-4-CHLORO-1, 5-BENZOTHIAZEPINE
WAMHOFF, H
MA, JJ
ACTA CHIMICA SINICA, 1987, 45 (02) : 166 - 171
[46] Reactions of tetrahydropyrido[4,5-d][1,2,4]triazolo[1,5-a]-pyrimidin-4-ones with activated alkynes. Synthesis of [1,2,4]triazolo[1′,5′:1,2]pyrimido[4,5-d]azocines
L. G. Voskressensky
T. N. Borisova
M. V. Ovcharov
E. A. Sorokina
V. N. Khrustalev
A. V. Varlamov
Russian Chemical Bulletin, 2012, 61 : 1603 - 1608
[47] One-Pot Synthesis of Dihydro[1,2,4]triazolo[1,5-a]pyrimidines and Dihydrobenzo[4,5] imidazo[1,2-a]pyrimidine Derivatives Catalyzed by Amberlyst-15
Ma, Huifang
Li, Wenbo
Ablajan, Keyume
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 39 (07) : 1945 - 1952
[48] New 1-(3-Nitrophenyl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepines: Synthesis and Computational Study
Kosychova, Lidija
Karalius, Antanas
Staniulyte, Zita
Sirutkaitis, Romualdas Aleksas
Palaima, Algirdas
Laurynenas, Audrius
Anusevicius, Zilvinas
MOLECULES, 2015, 20 (04): : 5392 - 5408
[49] ASSAY METHODS FOR USE IN STABILITY STUDIES OF 2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE
KITSON, GE
HUDSON, HE
DICKINSON, NA
ANALYST, 1976, 101 (1203) : 463 - 468
[50] A FACILE SYNTHESIS OF SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[3,4-D]-PYRIMIDINE AND 1,2,3,4-TETRAHYDROPYRAZOLO[1,5-A]TRIAZINE DERIVATIVES
VISHWAKARMA, JN
MOFIZUDDIN, M
ILA, H
JUNJAPPA, H
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1988, 25 (05) : 1387 - 1390

← 1 2 3 4 5 →