STUDIES ON ANNELATED [1,4]BENZOTHIAZINES AND [1,5]BENZOTHIAZEPINES .5. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-2 ALKYLAMINO DERIVATIVES OF 4,5-DIHYDRO-S-TRIAZOLO[3,4-D]-1,5-BENZOTHIAZEPINE

被引：15

作者：

AMBROGI, V ^{[1
]}

GIAMPIETRI, A ^{[1
]}

GRANDOLINI, G ^{[1
]}

PERIOLI, L ^{[1
]}

RICCI, M ^{[1
]}

TUTTOBELLO, L ^{[1
]}

机构：

[1] UNIV PERUGIA,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,SEZ FARMACOL,I-06100 PERUGIA,ITALY

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 09期

关键词：

D O I：

10.1002/ardp.19923250909

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new series of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine has been accomplished starting from 2,3-dihydro-1,5-benzothiazepin-4(5H)ones and their 2-methyl and 2-aryl derivatives. - All the compounds were tested in vitro for their antimicrobial activity, but none of them showed remarkable activity. The tricyclic compounds 7a-j, 8a-j, 9a-j, 10a-j, and 11a-j were also screened for their CNS activity in mice and several of them showed interesting activity.

引用

页码：569 / 577

页数：9

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