STUDIES ON ANNELATED [1,4]BENZOTHIAZINES AND [1,5]BENZOTHIAZEPINES .5. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-2 ALKYLAMINO DERIVATIVES OF 4,5-DIHYDRO-S-TRIAZOLO[3,4-D]-1,5-BENZOTHIAZEPINE

被引：15

作者：

AMBROGI, V ^{[1
]}

GIAMPIETRI, A ^{[1
]}

GRANDOLINI, G ^{[1
]}

PERIOLI, L ^{[1
]}

RICCI, M ^{[1
]}

TUTTOBELLO, L ^{[1
]}

机构：

[1] UNIV PERUGIA,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,SEZ FARMACOL,I-06100 PERUGIA,ITALY

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 09期

关键词：

D O I：

10.1002/ardp.19923250909

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new series of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine has been accomplished starting from 2,3-dihydro-1,5-benzothiazepin-4(5H)ones and their 2-methyl and 2-aryl derivatives. - All the compounds were tested in vitro for their antimicrobial activity, but none of them showed remarkable activity. The tricyclic compounds 7a-j, 8a-j, 9a-j, 10a-j, and 11a-j were also screened for their CNS activity in mice and several of them showed interesting activity.

引用

页码：569 / 577

页数：9

共 50 条

[1] STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .3. SYNTHESIS AND CNS ACTIVITY OF SOME 1-SUBSTITUTED DERIVATIVES OF THE NOVEL HETEROCYCLIC SYSTEM 4,5-DIHYDRO-S-TRIAZOLO [3,4-D]-1,5-BENZOTHIAZEPINE
AMBROGI, V
GRANDOLINI, G
ROSSI, C
TIRALTI, MC
FARMACO-EDIZIONE SCIENTIFICA, 1987, 42 (08): : 575 - 583
[2] STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .4. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NEW 1-SUBSTITUTED DERIVATIVES OF 4H-SYM-TRIAZOLO[3,4-C]-1,4-BENZOTHIAZINE AND 4,5-DIHYDRO-SYM-TRIAZOLO[3,4-D]-1,5-BENZOTHIAZEPINE
AMBROGI, V
GRANDOLINI, G
PERIOLI, L
DEMIA, GM
RICCI, M
TUTTOBELLO, L
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1991, 26 (08) : 835 - 838
[3] STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .6. SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF 1-ALKYLAMINOMETHYL-4,5-DIHYDRO-S-TRIAZOLO[3,4-D]-1,5-BENZOTHIAZEPINES
AMBROGI, V
GRANDOLINI, G
PERIOLI, L
GIAMPIETRI, A
FARMACO, 1993, 48 (05): : 653 - 664
[4] NMR-SPECTRA AND CONFORMATIONAL-ANALYSIS OF SOME 4,5-DIHYDRO-S-TRIAZOLO[3,4-D][1,5]BENZOTHIAZEPINE DERIVATIVES
AMBROGI, V
GRANDOLINI, G
PERIOLI, L
KAJTARPEREDY, M
RADICS, L
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1994, 31 (06) : 1349 - 1352
[5] STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .7. SYNTHESIS AND INHIBITION OF BENZODIAZEPINE RECEPTOR-BINDING OF SOME 4,5-DIHYDRO-TETRAZOLO[5,1-D]-1,5-BENZOTHIAZEPINES AND 5-PHENYL-S-TRIAZOLO[3,4-D]-1,5-BENZOTHIAZEPINES
AMBROGI, V
GRANDOLINI, G
PERIOLI, L
GIUSTI, L
LUCACCHINI, A
MARTINI, C
FARMACO, 1993, 48 (05): : 665 - 676
[6] STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .1. SYNTHESIS OF 4H-S-TRIAZOLO [3,4-C]-1,4-BENZOTHIAZINE AND DERIVATIVES WITH POTENTIAL CNS ACTIVITY
GRANDOLINI, G
ROSSI, C
TIRALTI, MC
ORZALESI, G
DEREGIS, M
FARMACO-EDIZIONE SCIENTIFICA, 1985, 40 (04): : 221 - 236
[7] STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .8. SYNTHESIS AND INHIBITION OF BENZODIAZEPINE RECEPTOR-BINDING OF SOME DERIVATIVES OF TRIAZINO[3,4-C]-1,4-BENZOTHIAZINE AND TRIAZINO[3,4-D]-1,5-BENZOTHIAZEPINE, 2 NEW HETEROCYCLIC RING-SYSTEMS
PERIOLI, L
AMBROGI, V
GRANDOLINI, G
GIUSTI, L
LUCACCHINI, A
MARTINI, C
FARMACO, 1994, 49 (04): : 245 - 251
[8] An expedient synthesis of novel [1,2,4]triazolo[3,2-d] [1,5]benzothiazepine] derivatives
Liu, XJ
Wang, QR
Liu, Y
Fan, YB
Ding, ZB
SYNTHESIS-STUTTGART, 2000, (03): : 435 - 441
[9] Synthesis of novel [1,2,4]triazolo[3,4-d][1,5] benzodiazepinones derivatives by 1,3-dipolar cycloaddition
Aatif, A
Baouid, A
Benharref, A
Hasnaoui, A
SYNTHETIC COMMUNICATIONS, 2000, 30 (15) : 2647 - 2659
[10] STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .2. SYNTHESIS OF NEW SERIES OF 1-SUBSTITUTED OR 2-SUBSTITUTED 4H-S-TRIAZOLO[3,4-C]-1,4-BENZOTHIAZINES AND RELATED-COMPOUNDS WITH POTENTIAL CNS ACTIVITY
GRANDOLINI, G
TIRALTI, MC
ROSSI, C
AMBROGI, V
ORZALESI, G
DEREGIS, M
FARMACO-EDIZIONE SCIENTIFICA, 1987, 42 (01): : 43 - 60

← 1 2 3 4 5 →