Multiphoton Tomography and Cross-Polarization Optical Coherence Tomography for Diagnosing Brain Gliomas: Pilot Study

被引:1
|
作者
Dudenkova, V. V. [1 ,6 ]
Yashin, K. S. [2 ,7 ]
Kiseleva, E. B. [1 ]
Kuznetsov, S. S. [3 ]
Timofeeva, L. B. [4 ]
Khalansky, A. S. [9 ]
Elagin, V. V. [1 ]
Gubarkova, E. V. [1 ]
Karabut, M. M. [1 ]
Pavlova, N. P. [1 ]
Medyanik, I. A. [8 ]
Kravets, L. Ya. [8 ]
Gladkova, N. D. [5 ]
机构
[1] Nizhny Novgorod State Med Acad, Lab Studying Opt Struct Biotissues, Inst Biomed Technol, 10-1 Minin & Pozharsky Sq, Nizhnii Novgorod 603005, Russia
[2] Nizhny Novgorod State Med Acad, Lab High Resolut Microscopy & Gene Technol, Inst Biomed Technol, 10-1 Minin & Pozharsky Sq, Nizhnii Novgorod 603005, Russia
[3] Nizhny Novgorod State Med Acad, Dept Pathol Anat, 10-1 Minin & Pozharsky Sq, Nizhnii Novgorod 603005, Russia
[4] Nizhny Novgorod State Med Acad, Dept Histol Cytol & Embryol, 10-1 Minin & Pozharsky Sq, Nizhnii Novgorod 603005, Russia
[5] Nizhny Novgorod State Med Acad, Inst Biomed Technol, Sci, 10-1 Minin & Pozharsky Sq, Nizhnii Novgorod 603005, Russia
[6] Nizhny Novgorod Reg Oncol Hosp, Fac Radiophys, 190 Rodionova St, Nizhnii Novgorod 603126, Russia
[7] Minist Hlth Russian Federat, Privolzhsky Fed Res Med Ctr, Dept Neurosurg, 18 Verkhne Volzhskaya Naberezhnaya St, Nizhnii Novgorod 603155, Russia
[8] Minist Hlth Russian Federat, Privolzhsky Fed Res Med Ctr, Grp Microneurosurg, 18 Verkhne Volzhskaya Naberezhnaya St, Nizhnii Novgorod 603155, Russia
[9] Res Inst Human Morphol, Lab Expt Histopathol Cent Nervous Syst, 3 Zurupy St, Moscow 117418, Russia
基金
俄罗斯科学基金会;
关键词
multiphoton tomography (MPT); cross-polarization optical coherence tomography (CP OCT); brain tumor rat model; glioma; glioblastoma; intraoperative diagnostics;
D O I
10.17691/stm2016.8.4.09
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Progress in the surgery of infiltratively growing gliomas is closely related to intraoperative diagnostics. Currently the most promising methods of optical imaging in the field of intraoperative identification of glioma boundaries and of grade of tumor are those providing high spatial resolution, such as optical coherence tomography (OCT) and multiphoton tomography (MPT). Nevertheless, for routine clinical use, evidence-based criteria are required. In this work the results of parallel ex vivo analysis of specimens of different grades of gliomas and of peritumoral areas obtained through the use of MPT and cross-polarization OCT (CP OCT) are compared with simultaneous histological descriptions and are presented in order to reveal the usefulness of each method in neurooncology.
引用
收藏
页码:64 / 73
页数:10
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