SCATTER FACTOR REGULATES VASCULAR ENDOTHELIAL-CELL MOTILITY

被引：25
|
作者：
ROSEN, EM
CARLEY, W
GOLDBERG, ID
机构：
[1] YALE UNIV,SCH MED,DEPT ANESTHESIOL,NEW HAVEN,CT 06510
[2] LONG ISL JEWISH MED CTR,DEPT RADIAT ONCOL,NEW HYDE PK,NY 11042
来源：
CANCER INVESTIGATION | 1990年 / 8卷 / 06期
关键词：
D O I：
10.3109/07357909009018936
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Scatter factors (SFs) are mesenchymal cell-derived cytokines which stimulate epithelial motility. SF purified from ras-transformed 3T3 cell supernatants markedly stimulated vascular endothelial cell migration at < 100 pM. Preliminary studies suggest endothelial lines with cobblestone (epithelioid) morphology respond to SF, while those lines with elongated cells do not respond. SFs may play roles in development and tissue repair.
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页码：647 / 650
页数：4
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