SCATTER FACTOR REGULATES VASCULAR ENDOTHELIAL-CELL MOTILITY

被引：25
|
作者：
ROSEN, EM
CARLEY, W
GOLDBERG, ID
机构：
[1] YALE UNIV,SCH MED,DEPT ANESTHESIOL,NEW HAVEN,CT 06510
[2] LONG ISL JEWISH MED CTR,DEPT RADIAT ONCOL,NEW HYDE PK,NY 11042
来源：
CANCER INVESTIGATION | 1990年 / 8卷 / 06期
关键词：
D O I：
10.3109/07357909009018936
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Scatter factors (SFs) are mesenchymal cell-derived cytokines which stimulate epithelial motility. SF purified from ras-transformed 3T3 cell supernatants markedly stimulated vascular endothelial cell migration at < 100 pM. Preliminary studies suggest endothelial lines with cobblestone (epithelioid) morphology respond to SF, while those lines with elongated cells do not respond. SFs may play roles in development and tissue repair.
引用
收藏
页码：647 / 650
页数：4
相关论文
共 50 条
  • [31] Membrane microviscosity regulates endothelial cell motility
    Prabar K. Ghosh
    Amit Vasanji
    Gurunathan Murugesan
    Steven J. Eppell
    Linda M. Graham
    Paul L. Fox
    Nature Cell Biology, 2002, 4 : 894 - 900
  • [32] Scatter factor promotes motility of human glioma and neuromicrovascular endothelial cells
    Lamszus, K
    Schmidt, NO
    Jin, L
    Laterra, J
    Zagzag, D
    Way, D
    Witte, M
    Weinand, M
    Goldberg, ID
    Westphal, M
    Rosen, EM
    INTERNATIONAL JOURNAL OF CANCER, 1998, 75 (01) : 19 - 28
  • [33] IDENTIFICATION OF THE KDR TYROSINE KINASE AS A RECEPTOR FOR VASCULAR ENDOTHELIAL-CELL GROWTH-FACTOR
    TERMAN, BI
    DOUGHERVERMAZEN, M
    CARRION, ME
    DIMITROV, D
    ARMELLINO, DC
    GOSPODAROWICZ, D
    BOHLEN, P
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 187 (03) : 1579 - 1586
  • [34] THE REGULATION OF ENDOTHELIAL-CELL MOTILITY BY P21 RAS
    FOX, PL
    SA, G
    DOBROWOLSKI, SF
    STACEY, DW
    ONCOGENE, 1994, 9 (12) : 3519 - 3526
  • [35] TUMOR-NECROSIS-FACTOR INFLUENCES PULMONARY VASCULAR ENDOTHELIAL-CELL ACTIN ORGANIZATION
    GOLDBLUM, SE
    DING, X
    CLINICAL RESEARCH, 1991, 39 (02): : A280 - A280
  • [36] VASCULAR ENDOTHELIAL-CELL PROLIFERATION FACTOR FROM PLATELETS - PARTIAL-PURIFICATION AND CHARACTERIZATION
    MIYAZONO, K
    OKABE, T
    URABE, A
    TAKAKU, F
    CELL STRUCTURE AND FUNCTION, 1985, 10 (04) : 477 - 477
  • [37] Rho regulates the hepatocyte growth factor/scatter factor-stimulated cell motility of human oral squamous cell carcinoma cells
    Kitajo, H
    Shibata, T
    Nagayasu, H
    Kawano, T
    Hamada, J
    Yamashita, T
    Arisue, M
    ONCOLOGY REPORTS, 2003, 10 (05) : 1351 - 1356
  • [38] ENDOTHELIAL-CELL AND VASCULAR DAMAGE IN THE SICKLE-CELL DISORDERS
    KLUG, PP
    KAYE, N
    JENSEN, WN
    BLOOD CELLS, 1982, 8 (01): : 175 - 184
  • [39] ENDOTHELIAL-CELL PRODUCTION OF TUMOR NECROSIS FACTOR
    CASEY, LC
    MODI, H
    SIMPSON, S
    FASEB JOURNAL, 1988, 2 (06): : A1599 - A1599
  • [40] ENDOTHELIAL-CELL ACTIVATION AS A PATHOGENETIC FACTOR IN PREECLAMPSIA
    ROBERTS, JM
    TAYLOR, RN
    GOLDFIEN, A
    SEMINARS IN PERINATOLOGY, 1991, 15 (01) : 86 - 93
12345