DETERMINATION OF ETOPOSIDE IN BLOOD BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：11
|
作者：
EISENBERG, EJ [1 ]
EICKHOFF, WM [1 ]
机构：
[1] STERLING WINTHROP INC,DEPT PHARMACEUT SCI,MALVERN,PA 19355
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 621卷 / 01期
关键词：
D O I：
10.1016/0378-4347(93)80084-H
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A liquid chromatographic (LC) method for determination of etoposide in dog blood is described. The technique includes solvent extraction of etoposide using a dichloroethane-hexane mixture and reconstitution of the drug in an aqueous reconstitution solution. The samples are analyzed by reversed-phase LC with electrochemical detection. Validation of the method demonstrated good sensitivity, precision and reproducibility. The method is useful for the study of etoposide pharmacokinetics in the dog.
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页码：110 / 114
页数：5
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