DETERMINATION OF ETOPOSIDE IN BLOOD BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：11

作者：

EISENBERG, EJ ^{[1
]}

EICKHOFF, WM ^{[1
]}

机构：

[1] STERLING WINTHROP INC,DEPT PHARMACEUT SCI,MALVERN,PA 19355

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 621卷 / 01期

关键词：

D O I：

10.1016/0378-4347(93)80084-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A liquid chromatographic (LC) method for determination of etoposide in dog blood is described. The technique includes solvent extraction of etoposide using a dichloroethane-hexane mixture and reconstitution of the drug in an aqueous reconstitution solution. The samples are analyzed by reversed-phase LC with electrochemical detection. Validation of the method demonstrated good sensitivity, precision and reproducibility. The method is useful for the study of etoposide pharmacokinetics in the dog.

引用

页码：110 / 114

页数：5

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