DETERMINATION OF ETOPOSIDE IN BLOOD BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：11
|
作者：
EISENBERG, EJ [1 ]
EICKHOFF, WM [1 ]
机构：
[1] STERLING WINTHROP INC,DEPT PHARMACEUT SCI,MALVERN,PA 19355
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 621卷 / 01期
关键词：
D O I：
10.1016/0378-4347(93)80084-H
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A liquid chromatographic (LC) method for determination of etoposide in dog blood is described. The technique includes solvent extraction of etoposide using a dichloroethane-hexane mixture and reconstitution of the drug in an aqueous reconstitution solution. The samples are analyzed by reversed-phase LC with electrochemical detection. Validation of the method demonstrated good sensitivity, precision and reproducibility. The method is useful for the study of etoposide pharmacokinetics in the dog.
引用
收藏
页码：110 / 114
页数：5
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