IDENTIFICATION OF HUMAN GENES INVOLVED IN REPAIR AND TOLERANCE OF DNA DAMAGE

被引：6
|
作者：
KAINA, B
FRITZ, G
COQUERELLE, T
机构：
[1] Kernforschungszentrum Karlsruhe, Institut für Genetik und für Toxikologie, Karlsruhe, W-7500
来源：
RADIATION AND ENVIRONMENTAL BIOPHYSICS | 1991年 / 30卷 / 01期
关键词：
D O I：
10.1007/BF01595570
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An overview is presented on strategies of cloning mammalian DNA repair genes. Complementation of human and rodent repair defects and mutagen hypersensitivities by chromosome and DNA mediated gene transfer and mRNA microinjection is described, and the features of the cloned human DNA repair genes are summarized. It is shown that transfection of repair deficient cell lines with cloned bacterial and human genes may give rise to protection from the genotoxic effects of mutagens. © 1991 Springer-Verlag.
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页码：1 / 19
页数：19
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