SELECTIVE LOCALIZATION OF C-ATRIAL NATRIURETIC PEPTIDE RECEPTORS IN THE RAT-BRAIN

被引：11

作者：

ZORAD, S ^{[1
]}

TSUTSUMI, K ^{[1
]}

SAAVEDRA, JM ^{[1
]}

机构：

[1] NIMH,CLIN SCI LAB,PHARMACOL SECT,9000 ROCKVILLE PIKE,BLDG 10,RM 2D-45,BETHESDA,MD 20892

来源：

BRAIN RESEARCH | 1992年 / 570卷 / 1-2期

关键词：

ATRIOPEPTIN; CLEARANCE RECEPTOR; CHOROID PLEXUS; MENINGES; OLFACTORY BULB;

D O I：

10.1016/0006-8993(92)90575-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the distribution of C atrial natriuretic peptide (C-ANP) receptors in the rat brain after incubation with I-125-rANP, and competition with the selective C-ANP receptor competitor C-ANP(4-23) (10(-6) M). C-ANP receptors were selectively localized to a few structures, the external plexiform layer of the olfactory bulb, the arachnoid mater and the choroid plexus, and their amount corresponds to 25%, 75% and 35%, respectively, of the ANP specific binding. These data suggest specialized functions for C-ANP receptors in brain.

引用

页码：149 / 153

页数：5

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