SELECTIVE LOCALIZATION OF C-ATRIAL NATRIURETIC PEPTIDE RECEPTORS IN THE RAT-BRAIN

被引：11
|
作者：
ZORAD, S [1 ]
TSUTSUMI, K [1 ]
SAAVEDRA, JM [1 ]
机构：
[1] NIMH,CLIN SCI LAB,PHARMACOL SECT,9000 ROCKVILLE PIKE,BLDG 10,RM 2D-45,BETHESDA,MD 20892
来源：
BRAIN RESEARCH | 1992年 / 570卷 / 1-2期
关键词：
ATRIOPEPTIN; CLEARANCE RECEPTOR; CHOROID PLEXUS; MENINGES; OLFACTORY BULB;
D O I：
10.1016/0006-8993(92)90575-T
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We studied the distribution of C atrial natriuretic peptide (C-ANP) receptors in the rat brain after incubation with I-125-rANP, and competition with the selective C-ANP receptor competitor C-ANP(4-23) (10(-6) M). C-ANP receptors were selectively localized to a few structures, the external plexiform layer of the olfactory bulb, the arachnoid mater and the choroid plexus, and their amount corresponds to 25%, 75% and 35%, respectively, of the ANP specific binding. These data suggest specialized functions for C-ANP receptors in brain.
引用
收藏
页码：149 / 153
页数：5
相关论文
共 50 条
12345