ASYMMETRIC-SYNTHESIS .24. BENZOQUINOLIZIDINE ANALOGS OF PODOPHYLLOTOXIN VIA THE CN(R, S) METHOD

被引：0

作者：

LIENARD, P ^{[1
]}

ROYER, J ^{[1
]}

QUIRION, JC ^{[1
]}

HUSSON, HP ^{[1
]}

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 22期

关键词：

ASYMMETRIC SYNTHESIS; BENZOQUINOLIZIDINE; AZAPODOPHYLLOTOXIN; STEREOCONTROLLED REDUCTION OF IMINIUM;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alkylation of 2-cyano-6-phenyloxazolopiperidine synthon 1 gave after reduction, the optically active pivotal amine 4. Bischler-Napieralski reaction of different aryl amides derived from 4 furnished the podophyllotoxin analogues 7, 8, and 9 after NaBH4 reduction.

引用

页码：2489 / 2492

页数：4

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