NEW POLYENIC ANTIBIOTICS ACTIVE AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA

被引:24
|
作者
WATANABE, T [1 ]
SUGIYAMA, T [1 ]
TAKAHASHI, M [1 ]
SHIMA, J [1 ]
YAMASHITA, K [1 ]
IZAKI, K [1 ]
FURIHATA, K [1 ]
SETO, H [1 ]
机构
[1] UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN
来源
JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 04期
关键词
D O I
10.7164/antibiotics.45.470
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The chemical structure of a unique polyenic antibiotic enacyloxin IIa (former name: fr. 2) produced by Frateuria (formerly Gluconobacter) sp. W-315 has been determined by extensive spectroscopic studies, in particular by NMR spectral analysis. It has a novel non-lactonic structure involving 3,4-dihydroxycyclohexanecarboxylic acid with a chlorine-containing polyenic and poly-hydroxy acyl side chain attached as an ester to the 3-hydroxyl substituent of the acid.
引用
收藏
页码:470 / 475
页数:6
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