CONFORMATION AND LENGTH OF THE SIGNAL SEQUENCE AFFECT PROCESSING OF SECRETORY PROTEIN

被引：6
|
作者：
KOHARA, A [1 ]
YAMAMOTO, Y [1 ]
KIKUCHI, M [1 ]
机构：
[1] PROT ENGN RES INST,2-3 FURUEDAI 6-CHOME,SUITA,OSAKA 565,JAPAN
来源：
FEBS LETTERS | 1992年 / 311卷 / 03期
关键词：
SIGNAL SEQUENCE; HUMAN LYSOZYME; SECRETION; TRANSLOCATION;
D O I：
10.1016/0014-5793(92)81108-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Processing of human lysozyme with artificially designed signal sequences was examined in an in vitro translation-translocation system and compared with their secretory capabilities in yeast. It has been shown that the conformation of the C-terminal region of the signal sequence and the length of the hydrophobic segment are important factors for efficient cleavage of the signal sequence.
引用
收藏
页码：226 / 230
页数：5
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