CONFORMATION AND LENGTH OF THE SIGNAL SEQUENCE AFFECT PROCESSING OF SECRETORY PROTEIN

被引：6

作者：

KOHARA, A ^{[1
]}

YAMAMOTO, Y ^{[1
]}

KIKUCHI, M ^{[1
]}

机构：

[1] PROT ENGN RES INST,2-3 FURUEDAI 6-CHOME,SUITA,OSAKA 565,JAPAN

来源：

FEBS LETTERS | 1992年 / 311卷 / 03期

关键词：

SIGNAL SEQUENCE; HUMAN LYSOZYME; SECRETION; TRANSLOCATION;

D O I：

10.1016/0014-5793(92)81108-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Processing of human lysozyme with artificially designed signal sequences was examined in an in vitro translation-translocation system and compared with their secretory capabilities in yeast. It has been shown that the conformation of the C-terminal region of the signal sequence and the length of the hydrophobic segment are important factors for efficient cleavage of the signal sequence.

引用

页码：226 / 230

页数：5

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