SIMIAN VIRUS-40 (SV40) SMALL T-ANTIGEN INHIBITS SV40 DNA-REPLICATION INVITRO

被引：13

作者：

CARBONE, M ^{[1
]}

HAUSER, J ^{[1
]}

CARTY, MP ^{[1
]}

RUNDELL, K ^{[1
]}

DIXON, K ^{[1
]}

LEVINE, AS ^{[1
]}

机构：

[1] NORTHWESTERN UNIV,DEPT MICROBIOL & IMMUNOL,CHICAGO,IL 60611

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 03期

关键词：

D O I：

10.1128/JVI.66.3.1804-1808.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.

引用

页码：1804 / 1808

页数：5

共 50 条

[31] MUTATIONS IN THE PHOSPHORYLATION SITES OF SIMIAN VIRUS-40 (SV40) T-ANTIGEN ALTER ITS ORIGIN DNA-BINDING SPECIFICITY FOR SITE-I OR SITE-II AND AFFECT SV40 DNA-REPLICATION ACTIVITY
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