SIMIAN VIRUS-40 (SV40) SMALL T-ANTIGEN INHIBITS SV40 DNA-REPLICATION INVITRO

被引：13
|
作者：
CARBONE, M [1 ]
HAUSER, J [1 ]
CARTY, MP [1 ]
RUNDELL, K [1 ]
DIXON, K [1 ]
LEVINE, AS [1 ]
机构：
[1] NORTHWESTERN UNIV,DEPT MICROBIOL & IMMUNOL,CHICAGO,IL 60611
来源：
JOURNAL OF VIROLOGY | 1992年 / 66卷 / 03期
关键词：
D O I：
10.1128/JVI.66.3.1804-1808.1992
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.
引用
收藏
页码：1804 / 1808
页数：5
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