ROLE OF THE BETA-AMYLOID PRECURSOR PROTEIN IN ALZHEIMERS-DISEASE

被引：100
|
作者：
ASHALL, F
GOATE, AM
机构：
[1] F. Ashall and A.M. Goate are, the Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 01期
关键词：
D O I：
10.1016/0968-0004(94)90173-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Deposition of beta-amyloid peptide in the brain is an early event in Alzheimer's disease, the most common cause of dementia. Studies of the beta-amyloid precursor protein (APP), which gives rise to beta-amyloid, are rapidly leading to a better understanding of the biochemical basis of the disease - a prerequisite for rational drug development.
引用
收藏
页码：42 / 46
页数：5
相关论文
共 50 条
  • [41] THE ROLE OF PERIVASCULAR AND MICROGLIAL CELLS IN FIBRILLOGENESIS OF BETA-AMYLOID AND PRP PROTEIN IN ALZHEIMERS-DISEASE AND SCRAPIE
    WISNIEWSKI, HM
    WEGIEL, J
    RESEARCH IN IMMUNOLOGY, 1992, 143 (06): : 642 - 645
  • [42] THE METABOLISM OF THE BETA-A4 AMYLOID PRECURSOR PROTEIN IN ALZHEIMERS-DISEASE
    MASTERS, CL
    WHYTE, S
    MOIR, R
    LYNCH, T
    LI, QX
    BEYREUTHER, K
    NEUROBIOLOGY OF AGING, 1994, 15 : S69 - S69
  • [43] BETA-AMYLOID NEUROTOXICITY AND NEURONAL DEGENERATION IN ALZHEIMERS-DISEASE
    KOWALL, NW
    NEUROBIOLOGY OF AGING, 1994, 15 (02) : 257 - 258
  • [44] BETA-A4 AMYLOID PROTEIN AND ITS PRECURSOR IN ALZHEIMERS-DISEASE
    BUSH, AI
    BEYREUTHER, K
    MASTERS, CL
    PHARMACOLOGY & THERAPEUTICS, 1992, 56 (01) : 97 - 117
  • [45] AMYLOID-BETA PROTEIN-PRECURSOR AND THE PATHOGENESIS OF ALZHEIMERS-DISEASE
    SELKOE, DJ
    CELL, 1989, 58 (04) : 611 - 612
  • [46] STUDIES OF AMYLOID BETA-PROTEIN PRECURSOR EXPRESSION IN ALZHEIMERS-DISEASE
    TANZI, RE
    HYMAN, BT
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1991, 640 : 149 - 154
  • [47] GENE DOSAGE OF THE AMYLOID-BETA PRECURSOR PROTEIN IN ALZHEIMERS-DISEASE
    PODLISNY, MB
    LEE, G
    SELKOE, DJ
    SCIENCE, 1987, 238 (4827) : 669 - 671
  • [48] DEVELOPMENT OF SMALL-MOLECULE PROBES FOR THE BETA-AMYLOID PROTEIN OF ALZHEIMERS-DISEASE
    KLUNK, WE
    DEBNATH, ML
    PETTEGREW, JW
    NEUROBIOLOGY OF AGING, 1994, 15 (06) : 691 - 698
  • [49] ALZHEIMERS-DISEASE - BETA-AMYLOID PRECURSOR PROTEIN MESSENGER-RNA EXPRESSION IN MONONUCLEAR BLOOD-CELLS
    ALLEN, JS
    MURPHY, GM
    ENG, LF
    STULTZ, KE
    DAVIES, HD
    PICKFORD, LB
    TINKLENBERG, JR
    NEUROSCIENCE LETTERS, 1991, 132 (01) : 109 - 112
  • [50] LACK OF VARIATION IN THE NUCLEOTIDE-SEQUENCE CORRESPONDING TO THE TRANSMEMBRANE DOMAIN OF THE BETA-AMYLOID PRECURSOR PROTEIN IN ALZHEIMERS-DISEASE
    ZUBENKO, GS
    STIFFLER, S
    FARR, J
    KOPP, U
    HUGHES, H
    KAPLAN, BB
    MOOSSY, J
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1993, 48 (03): : 131 - 136
12345