ROLE OF THE BETA-AMYLOID PRECURSOR PROTEIN IN ALZHEIMERS-DISEASE

被引：100

作者：

ASHALL, F

GOATE, AM

机构：

[1] F. Ashall and A.M. Goate are, the Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 01期

关键词：

D O I：

10.1016/0968-0004(94)90173-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deposition of beta-amyloid peptide in the brain is an early event in Alzheimer's disease, the most common cause of dementia. Studies of the beta-amyloid precursor protein (APP), which gives rise to beta-amyloid, are rapidly leading to a better understanding of the biochemical basis of the disease - a prerequisite for rational drug development.

引用

页码：42 / 46

页数：5

共 50 条

[21] ALZHEIMERS-DISEASE AND THE BETA-AMYLOID GENE
HARRISON, PJ
BRITISH MEDICAL JOURNAL, 1991, 302 (6791): : 1478 - 1479
[22] LEWY BODIES CONTAIN BETA-AMYLOID PRECURSOR PROTEINS OF ALZHEIMERS-DISEASE
ARAI, H
LEE, VMY
HILL, WD
GREENBERG, BD
TROJANOWSKI, JQ
BRAIN RESEARCH, 1992, 585 (1-2) : 386 - 390
[23] MODEL SYSTEMS TO STUDY THE BETA-AMYLOID PROTEIN OF ALZHEIMERS-DISEASE
SANDHU, FA
AGE, 1994, 17 (01) : 7 - 11
[24] PHYSIOLOGICAL PRODUCTION OF THE BETA-AMYLOID PROTEIN AND THE MECHANISM OF ALZHEIMERS-DISEASE
SELKOE, DJ
TRENDS IN NEUROSCIENCES, 1993, 16 (10) : 403 - 409
[25] ABERRANT PROTEOLYSIS OF THE BETA-AMYLOID PRECURSOR PROTEIN IN FAMILIAL ALZHEIMERS-DISEASE LYMPHOBLASTOID-CELLS
MATSUMOTO, A
FUJIWARA, Y
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 217 (01): : 21 - 27
[26] DECREASED BETA-AMYLOID SENSITIVITY IN ALZHEIMERS-DISEASE
ECKERT, A
FORSTL, H
HARTMANN, H
MULLER, WE
LANCET, 1993, 342 (8874): : 805 - 806
[27] BETA-AMYLOID GENE DOSAGE IN ALZHEIMERS-DISEASE
MURDOCH, GH
MANUELIDIS, L
KIM, JH
MANUELIDIS, EE
NUCLEIC ACIDS RESEARCH, 1988, 16 (01) : 357 - 357
[28] NEURODEGENERATION, ALZHEIMERS-DISEASE, AND BETA-AMYLOID TOXICITY
HOYER, S
LIFE SCIENCES, 1994, 55 (25-26) : 1977 - 1983
[29] BETA-AMYLOID IN ALZHEIMERS-DISEASE - THERAPEUTIC IMPLICATIONS
POLLARD, HB
ROJAS, E
ARISPE, N
CNS DRUGS, 1994, 2 (01) : 1 - 6
[30] FAMILIAL ALZHEIMERS-DISEASE - BETA-AMYLOID RESURRECTED
WRIGHT, AF
GOEDERT, M
HASTIE, ND
NATURE, 1991, 349 (6311) : 653 - 654

← 1 2 3 4 5 →