ROLE OF THE BETA-AMYLOID PRECURSOR PROTEIN IN ALZHEIMERS-DISEASE

被引：100

作者：

ASHALL, F

GOATE, AM

机构：

[1] F. Ashall and A.M. Goate are, the Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 01期

关键词：

D O I：

10.1016/0968-0004(94)90173-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deposition of beta-amyloid peptide in the brain is an early event in Alzheimer's disease, the most common cause of dementia. Studies of the beta-amyloid precursor protein (APP), which gives rise to beta-amyloid, are rapidly leading to a better understanding of the biochemical basis of the disease - a prerequisite for rational drug development.

引用

页码：42 / 46

页数：5

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