PREVENTION OF PRIMARY PROSTATE-CANCER IN LOBUND-WISTAR RATS BY N-(4-HYDROXYPHENYL)RETINAMIDE

被引：0
|
作者：
POLLARD, M [1 ]
LUCKERT, PH [1 ]
SPORN, MB [1 ]
机构：
[1] NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892
来源：
CANCER RESEARCH | 1991年 / 51卷 / 13期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report for the first time that a synthetic retinoid, N-(4-hydroxyphenyl) retinamide, can prevent the development of both primary and metastatic tumors in an animal model of metastasizing primary prostate cancer. Prostatic adenocarcinomas were induced in high incidence in Lobund-Wistar rats by initiation with methylnitrosourea i.v. and promotion with testosterone. Feeding of N-(4-hydroxyphenyl)retinamide to these rats during the latency period markedly diminished the final incidence of both primary and metastatic prostate carcinomas.
引用
收藏
页码：3610 / 3611
页数：2
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