PREVENTION OF PRIMARY PROSTATE-CANCER IN LOBUND-WISTAR RATS BY N-(4-HYDROXYPHENYL)RETINAMIDE

We report for the first time that a synthetic retinoid, N-(4-hydroxyphenyl) retinamide, can prevent the development of both primary and metastatic tumors in an animal model of metastasizing primary prostate cancer. Prostatic adenocarcinomas were induced in high incidence in Lobund-Wistar rats by initiation with methylnitrosourea i.v. and promotion with testosterone. Feeding of N-(4-hydroxyphenyl)retinamide to these rats during the latency period markedly diminished the final incidence of both primary and metastatic prostate carcinomas.