Polymorphisms of MicroRNA-146a Gene in Behcet's Disease in Iraqi Patients

被引：0

作者：

Mohsen, Israa Harjan ^{[1
]}

Al-Terehi, Mona N. ^{[1
]}

Mugheer, Abbas Hussein ^{[2
]}

Al-Hachamy, Ahmed ^{[1
]}

Al-Saadi, Ali H. ^{[1
]}

机构：

[1] Univ Babylon, Coll Sci, Hillah, Iraq

[2] Univ Babylon, Coll Basic Educ, Hillah, Iraq

来源：

JOURNAL OF PURE AND APPLIED MICROBIOLOGY | 2018年 / 12卷 / 03期

关键词：

Haplotypes; Mir-146a .Pcr-SScP technique; Polymorphisms;

D O I：

10.22207/JPAM.12.3.63

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study was carried out to detect the association of miR-146a haplotypes polymorphisms with Behcet's Disease in Iraqi patients, PCR-SSCP technique used in present study, blood was used to DNA extraction, the results show that there was strong association between miR-146a and Behcet's Disease there were two patterns (A and B), polymorphisms show significant differences (p>0.05) between patients and control where haplotype A was appeared in control with (4%) while in patients (43%) and haplotype B was appeared in control with (96%) while in patients (57%). The present study concluded that there was association between miR-146a polymorphisms with Behcet's Disease, our finding need more investigation to use this polymorphism as early indication of Behcet's Disease incidence.

引用

页码：1579 / 1582

页数：4

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