Polymorphisms of MicroRNA-146a Gene in Behcet's Disease in Iraqi Patients

被引：0
|
作者：
Mohsen, Israa Harjan [1 ]
Al-Terehi, Mona N. [1 ]
Mugheer, Abbas Hussein [2 ]
Al-Hachamy, Ahmed [1 ]
Al-Saadi, Ali H. [1 ]
机构：
[1] Univ Babylon, Coll Sci, Hillah, Iraq
[2] Univ Babylon, Coll Basic Educ, Hillah, Iraq
来源：
JOURNAL OF PURE AND APPLIED MICROBIOLOGY | 2018年 / 12卷 / 03期
关键词：
Haplotypes; Mir-146a .Pcr-SScP technique; Polymorphisms;
D O I：
10.22207/JPAM.12.3.63
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The present study was carried out to detect the association of miR-146a haplotypes polymorphisms with Behcet's Disease in Iraqi patients, PCR-SSCP technique used in present study, blood was used to DNA extraction, the results show that there was strong association between miR-146a and Behcet's Disease there were two patterns (A and B), polymorphisms show significant differences (p>0.05) between patients and control where haplotype A was appeared in control with (4%) while in patients (43%) and haplotype B was appeared in control with (96%) while in patients (57%). The present study concluded that there was association between miR-146a polymorphisms with Behcet's Disease, our finding need more investigation to use this polymorphism as early indication of Behcet's Disease incidence.
引用
收藏
页码：1579 / 1582
页数：4
相关论文
共 50 条
  • [11] Microbiome-Mediated Upregulation of MicrorNA-146a in Sporadic Alzheimer's Disease
    Zhao, Yuhai
    Lukiw, Walter J.
    FRONTIERS IN NEUROLOGY, 2018, 9
  • [12] Under-expression of microRNA-146a and 21 and their association with Crohn’s disease
    Mohammad Mirzakhani
    Ali Khalili
    Mehdi Shahbazi
    Saeid Abediankenari
    Soheil Ebrahimpour
    Mousa Mohammadnia-Afrouzi
    Indian Journal of Gastroenterology, 2020, 39 : 405 - 410
  • [13] IRAQI PATIENTS WITH BEHCET'S DISEASE IN MULTIDISCIPLINE CLINIC
    Sharquie, Khalifa E.
    Al-Rawi, Ziad
    Araji, Adnan
    Hayani, Raafa
    Abdali, Samara M.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2008, 26 (04) : S4 - S4
  • [14] Increased expression of microRNA-122, microRNA-146a and microRNA-155 in intestinal mucosa of pediatric patients with Crohn's disease
    Beres, N. J.
    Szabo, D.
    Arato, A.
    Kiss, A.
    Lendvai, G.
    Veres, G.
    JOURNAL OF CROHNS & COLITIS, 2014, 8 : S87 - S87
  • [15] Clinical Significance of microRNA-146a in Patients with Ulcerative Colitis
    Feng, Juan
    Zhu, Yunyan
    Chen, Liang
    Wang, Min
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2020, 50 (04): : 463 - 467
  • [16] Delay in prion disease incubation time in transgenic mice with a microRNA-146a gene deletion
    Saba, R.
    Huzarewich, Rhiannon
    Gushue, Shantel
    Abrenica, Bernard
    Niu, Yulian
    Booth, Stephanie
    PRION, 2012, 6 : 63 - 63
  • [17] MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet's disease
    Shaker, Olfat G.
    Abdelaleem, Omayma O.
    Fouad, Nermeen A.
    Ahmed, Naglaa A.
    Hussein, Hoda A.
    Ibrahem, Enas G.
    Mohamed, Abdelrahmaan A.
    Ahmed, Othman M.
    Ali, Doaa Y.
    ARCHIVES OF MEDICAL SCIENCE, 2022, 18 (06) : 1467 - 1474
  • [18] Four microRNA gene polymorphisms are associated with Iraqi patients with colorectal cancer
    Jameel, Zahraa Isam
    EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS, 2024, 25 (01)
  • [19] Four microRNA gene polymorphisms are associated with Iraqi patients with colorectal cancer
    Zahraa Isam Jameel
    Egyptian Journal of Medical Human Genetics, 25
  • [20] MicroRNA-146a regulates the expression of the Aβ1-42 protein in Alzheimer's disease
    Huang, P.
    Xu, M.
    He, Y-X
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2021, 25 (04) : 2003 - 2012
12345