PROLACTIN-INDUCED ANALGESIA IS DEPENDENT ON ATP-SENSITIVE POTASSIUM CHANNELS

被引：13
|
作者：
SHEWADE, DG [1 ]
RAMASWAMY, S [1 ]
机构：
[1] JAWAHARLAL INST POSTGRAD MED EDUC & RES,DEPT PHARMACOL,PONDICHERRY 605006,INDIA
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1995年 / 22卷 / 09期
关键词：
ANALGESIA; GLIBENCLAMIDE; POTASSIUM CHANNELS; PROLACTIN;
D O I：
10.1111/j.1440-1681.1995.tb02079.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The role of ATP sensitive potassium channels in the analgesic activity of prolactin (PRL) was studied in mice using glibenclamide and minoxidil, a blocker and an opener of these channel, respectively. 2. Pre-treatment with glibenclamide attenuated the analgesic activity of PRL while treatment with minoxidil potentiated the activity. 3. It is concluded that PRL, similar to morphine, utilizes ATP sensitive potassium channels in eliciting the analgesic response.
引用
收藏
页码：635 / 636
页数：2
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