PROLACTIN-INDUCED ANALGESIA IS DEPENDENT ON ATP-SENSITIVE POTASSIUM CHANNELS

被引：13
|
作者：
SHEWADE, DG [1 ]
RAMASWAMY, S [1 ]
机构：
[1] JAWAHARLAL INST POSTGRAD MED EDUC & RES,DEPT PHARMACOL,PONDICHERRY 605006,INDIA
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1995年 / 22卷 / 09期
关键词：
ANALGESIA; GLIBENCLAMIDE; POTASSIUM CHANNELS; PROLACTIN;
D O I：
10.1111/j.1440-1681.1995.tb02079.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The role of ATP sensitive potassium channels in the analgesic activity of prolactin (PRL) was studied in mice using glibenclamide and minoxidil, a blocker and an opener of these channel, respectively. 2. Pre-treatment with glibenclamide attenuated the analgesic activity of PRL while treatment with minoxidil potentiated the activity. 3. It is concluded that PRL, similar to morphine, utilizes ATP sensitive potassium channels in eliciting the analgesic response.
引用
收藏
页码：635 / 636
页数：2
相关论文
共 50 条
  • [21] REGULATION OF CHOLECYSTOKININ SECRETION BY ATP-SENSITIVE POTASSIUM CHANNELS
    MANGEL, AW
    PRPIC, V
    SNOW, ND
    BASAVAPPA, S
    HURST, LJ
    SHARARA, AI
    LIDDLE, RA
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1994, 267 (04): : G595 - G600
  • [22] ATP-sensitive potassium channels in cultured arterial segments
    Kleppisch, T
    Winter, B
    Nelson, MT
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 271 (06): : H2462 - H2468
  • [23] ANESTHETIC PHENCYCLIDINE, BLOCKER OF THE ATP-SENSITIVE POTASSIUM CHANNELS
    KOKOZ, YM
    ALEKSEEV, AE
    POVZUN, AA
    KORYSTOVA, AF
    PERESSAAD, H
    FEBS LETTERS, 1994, 337 (03) : 277 - 280
  • [24] Anionic phospholipids activate ATP-sensitive potassium channels
    Fan, Z
    Makielski, JC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (09) : 5388 - 5395
  • [25] THE ROLE OF ATP-SENSITIVE POTASSIUM CHANNELS IN MYOCARDIAL PROTECTION
    CASON, BA
    GORDON, HJ
    AVERY, EG
    HICKEY, RF
    JOURNAL OF CARDIAC SURGERY, 1995, 10 (04) : 441 - 444
  • [26] ATP-sensitive potassium channels: Structures, functions, and pathophysiology
    Inagaki, N
    Seino, S
    JAPANESE JOURNAL OF PHYSIOLOGY, 1998, 48 (06): : 397 - 412
  • [27] ATP-SENSITIVE POTASSIUM CHANNELS ARE NOT EXPRESSED IN BRAIN MICROVESSELS
    SULLIVAN, HC
    HARIK, SI
    BRAIN RESEARCH, 1993, 612 (1-2) : 336 - 338
  • [28] THERAPEUTIC MODULATION OF ATP-SENSITIVE POTASSIUM CHANNELS IN ISCHEMIA
    COLE, W
    AEILLO, EA
    CARDIOVASCULAR RESEARCH, 1994, 28 (02) : 286 - 287
  • [29] Protein folding disease and ATP-sensitive potassium channels
    Sanbe, Atsushi
    Aoyagi, Toshinori
    Tezuka, Yu
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124 : 46P - 46P
  • [30] ATP-Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles
    Tinker, Andrew
    Aziz, Qadeer
    Li, Yiwen
    Specterman, Mark
    COMPREHENSIVE PHYSIOLOGY, 2018, 8 (04) : 1463 - 1511
12345