A NEW METABOLITE OF 2,4,3',4'-TETRACHLOROBIPHENYL IN RAT FECES

被引：6
|
作者：
KOGA, N [1 ]
SHINYAMA, A [1 ]
ISHIDA, C [1 ]
HANIOKA, N [1 ]
YOSHIMURA, H [1 ]
机构：
[1] KYUSHU UNIV, FAC PHARMACEUT SCI, HIGASHI KU, FUKUOKA 812, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 12期
关键词：
2,4,3',4'-TETRACHLOROBIPHENYL; METABOLISM; GC-MS; NIH-SHIFT; 4-HYDROXY-2,5,3',4'-TETRACHLOROBIPHENYL;
D O I：
10.1248/cpb.40.3338
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Metabolism in vivo of 2,4,3',4'-tetrachlorobiphenyl (TCB) was further studied using male Wistar rats. When the extract of feces of rats given TCB with chloroform was methylated and applied to gas chromatography (GC)-mass spectrometry (MS), a new metabolite was detected. The structure of this new metabolite was 4-hydroxy-2,5,3'4'-TCB based on both its retention time in GC and comparison of the mass spectrum with that of the synthetic sample. 4-Hydroxy-2,5,3',4'-TCB was assumed to be formed via a 4,5-oxide intermediate followed by NIH-shift of a chlorine atom at 4-position.
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页码：3338 / 3339
页数：2
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