A NEW METABOLITE OF 2,4,3',4'-TETRACHLOROBIPHENYL IN RAT FECES

被引：6

作者：

KOGA, N ^{[1
]}

SHINYAMA, A ^{[1
]}

ISHIDA, C ^{[1
]}

HANIOKA, N ^{[1
]}

YOSHIMURA, H ^{[1
]}

机构：

[1] KYUSHU UNIV, FAC PHARMACEUT SCI, HIGASHI KU, FUKUOKA 812, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 12期

关键词：

2,4,3',4'-TETRACHLOROBIPHENYL; METABOLISM; GC-MS; NIH-SHIFT; 4-HYDROXY-2,5,3',4'-TETRACHLOROBIPHENYL;

D O I：

10.1248/cpb.40.3338

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Metabolism in vivo of 2,4,3',4'-tetrachlorobiphenyl (TCB) was further studied using male Wistar rats. When the extract of feces of rats given TCB with chloroform was methylated and applied to gas chromatography (GC)-mass spectrometry (MS), a new metabolite was detected. The structure of this new metabolite was 4-hydroxy-2,5,3'4'-TCB based on both its retention time in GC and comparison of the mass spectrum with that of the synthetic sample. 4-Hydroxy-2,5,3',4'-TCB was assumed to be formed via a 4,5-oxide intermediate followed by NIH-shift of a chlorine atom at 4-position.

引用

页码：3338 / 3339

页数：2

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