LOCALIZATION OF THE GROWTH-HORMONE GENE TO THE DISTAL HALF OF MOUSE CHROMOSOME-11

A DNA fragment size variant for the growth hormone gene, Gh, has been identified among inbred strains of mice. The inbred strains SM J and CAST Ei carry the less frequent allele Ghb and 11 other strains carry the Ghα allele. Segregation analysis of data from two crosses involving SM J and NZB BINJ and a cross involving BALB cJ and CAST Ei confirmed the assignment of Gh to mouse chromosome 11 and placed the locus 2.6 ± 1.8 map units distal to Erba (avian erythroblastosis oncogene A), a position consistent with the assignment of the Gh locus to the q22-q24 region of chromosome 17 on the human map. Segregation analysis also refined the location of Sparc (secreted acidic cysteine-rich glycoprotein) on mouse chromosome 11 to a position 16.7 ± 4.2 map units proximal to Evi-2 (ecotropic viral integration site 2). © 1990.