LOCALIZATION OF THE GROWTH-HORMONE GENE TO THE DISTAL HALF OF MOUSE CHROMOSOME-11

被引：10
|
作者：
ELLIOTT, RW [1 ]
LEE, BK [1 ]
EICHER, EM [1 ]
机构：
[1] JACKSON LAB,BAR HARBOR,ME 04609
来源：
GENOMICS | 1990年 / 8卷 / 03期
关键词：
D O I：
10.1016/0888-7543(90)90051-U
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A DNA fragment size variant for the growth hormone gene, Gh, has been identified among inbred strains of mice. The inbred strains SM J and CAST Ei carry the less frequent allele Ghb and 11 other strains carry the Ghα allele. Segregation analysis of data from two crosses involving SM J and NZB BINJ and a cross involving BALB cJ and CAST Ei confirmed the assignment of Gh to mouse chromosome 11 and placed the locus 2.6 ± 1.8 map units distal to Erba (avian erythroblastosis oncogene A), a position consistent with the assignment of the Gh locus to the q22-q24 region of chromosome 17 on the human map. Segregation analysis also refined the location of Sparc (secreted acidic cysteine-rich glycoprotein) on mouse chromosome 11 to a position 16.7 ± 4.2 map units proximal to Evi-2 (ecotropic viral integration site 2). © 1990.
引用
收藏
页码：591 / 594
页数：4
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