DETERMINATION OF SALBUTAMOL-RELATED IMPURITIES BY CAPILLARY ELECTROPHORESIS

被引：64
|
作者：
ALTRIA, KD
机构：
[1] Pharmaceutical Analysis, Glaxo Group Research, Ware, Herts. SG12 0DP, Park Road
来源：
JOURNAL OF CHROMATOGRAPHY | 1993年 / 634卷 / 02期
关键词：
D O I：
10.1016/0021-9673(93)83020-S
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
This paper describes the use and capabilities of capillary electrophoresis (CE) in the determination of two dimeric impurities present in salbutamol sulphate drug substance. Acceptable measures of detector linearity of response over the typical impurity range, detection limits, precision of peak area and migration times were obtained. The results obtained by CE were directly compared to those obtained by HPLC and TLC. The data shows agreement between the three techniques.
引用
收藏
页码：323 / 328
页数：6
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