HIGH-SPEED DETERMINATION OF DRUG-RELATED IMPURITIES BY CAPILLARY ELECTROPHORESIS EMPLOYING COMMERCIAL INSTRUMENTATION

被引：38
|
作者：
ALTRIA, KD
机构：
[1] Pharmaceutical Analysis, Glaxo Group Research, Ware, Herts., Park Road
来源：
JOURNAL OF CHROMATOGRAPHY | 1993年 / 636卷 / 01期
关键词：
D O I：
10.1016/0021-9673(93)80064-F
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
High-speed capillary electrophoresis (HSCE) separations of pharmaceuticals are presented with high efficiency separations being achieved typically within 2 min. These results are obtained by applying high voltages across relatively short capillaries. Separation selectivity is shown to be similar to normal-speed CE. Quantitative HSCE impurity results compare well to those achieved by CE, TLC and HPLC. Analytical method validation criteria for HSCE such as linearity, precision and limits of detection are assessed.
引用
收藏
页码：125 / 132
页数：8
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