NEUROPEPTIDE-Y AND TYROSINE-HYDROXYLASE MESSENGER-RNA LEVELS IN THE LOCUS-COERULEUS SHOW SIMILAR INCREASES AFTER RESERPINE TREATMENT

被引：9
|
作者：
FOSTER, OJF [1 ]
BISWAS, S [1 ]
LIGHTMAN, SL [1 ]
机构：
[1] WESTMINSTER MED SCH & HOSP,NEUROENDOCRINOL UNIT,LONDON SW1P 2AP,ENGLAND
来源：
NEUROPEPTIDES | 1991年 / 18卷 / 03期
关键词：
D O I：
10.1016/0143-4179(91)90105-R
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 43h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250% of control values (p < 0.05). The level of beta-tubulin mRNA was unaffected by reserpine administration. The similar and selective increase in TH and NPY mRNA in the LC following reserpine administration suggests that NPY may play a role in the neurotransmitter function of this catecholaminergic nucleus.
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页码：137 / 141
页数：5
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