NEUROPEPTIDE-Y AND TYROSINE-HYDROXYLASE MESSENGER-RNA LEVELS IN THE LOCUS-COERULEUS SHOW SIMILAR INCREASES AFTER RESERPINE TREATMENT

被引：9

作者：

FOSTER, OJF ^{[1
]}

BISWAS, S ^{[1
]}

LIGHTMAN, SL ^{[1
]}

机构：

[1] WESTMINSTER MED SCH & HOSP,NEUROENDOCRINOL UNIT,LONDON SW1P 2AP,ENGLAND

来源：

NEUROPEPTIDES | 1991年 / 18卷 / 03期

关键词：

D O I：

10.1016/0143-4179(91)90105-R

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 43h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250% of control values (p < 0.05). The level of beta-tubulin mRNA was unaffected by reserpine administration. The similar and selective increase in TH and NPY mRNA in the LC following reserpine administration suggests that NPY may play a role in the neurotransmitter function of this catecholaminergic nucleus.

引用

页码：137 / 141

页数：5

共 50 条

[31] EFFECT OF GLUCOSE AND INSULIN CONCENTRATIONS ON FETAL BRAIN NEUROPEPTIDE-Y MESSENGER-RNA LEVELS
SINGH, BS
SCHROEDER, RE
SADIG, HF
DEVASKAR, SU
PEDIATRIC RESEARCH, 1994, 35 (04) : A207 - A207
[32] COLD STRESS INCREASES NEUROPEPTIDE-Y MESSENGER-RNA IN MOUSE HYPOTHALAMUS AND ADRENAL-GLAND
KIM, J
HENNESSEY, K
CHUA, SC
LEIBEL, RL
HIRSCH, J
FASEB JOURNAL, 1991, 5 (05): : A1320 - A1320
[33] DIFFERENCES IN THE EFFECTS OF MEMBRANE DEPOLARIZATION ON LEVELS OF PREPROSOMATOSTATIN MESSENGER-RNA AND TYROSINE-HYDROXYLASE MESSENGER-RNA IN RAT SYMPATHETIC NEURONS INVIVO AND IN CULTURE
SPIEGEL, K
KREMER, NE
KESSLER, JA
MOLECULAR BRAIN RESEARCH, 1989, 5 (01): : 23 - 29
[34] SUBPOPULATIONS OF MESENCEPHALIC DOPAMINERGIC-NEURONS EXPRESS DIFFERENT LEVELS OF TYROSINE-HYDROXYLASE MESSENGER-RNA
WEISSWUNDER, LT
CHESSELET, MF
JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 303 (03) : 478 - 488
[35] ELEVATED TYROSINE-HYDROXYLASE MESSENGER-RNA LEVELS IN THE ADRENAL-MEDULLA OF SPONTANEOUSLY HYPERTENSIVE RATS
KUMAI, T
TANAKA, M
WATANABE, M
KOBAYASHI, S
JAPANESE JOURNAL OF PHARMACOLOGY, 1994, 65 (04): : 367 - 369
[36] CHRONIC COCAINE ADMINISTRATION INCREASES CNS TYROSINE-HYDROXYLASE ENZYME-ACTIVITY AND MESSENGER-RNA LEVELS AND TRYPTOPHAN-HYDROXYLASE ENZYME-ACTIVITY LEVELS
VRANA, SL
VRANA, KE
KOVES, TR
SMITH, JE
DWORKIN, SI
JOURNAL OF NEUROCHEMISTRY, 1993, 61 (06) : 2262 - 2268
[37] HYPOTHALAMIC-LESIONS INCREASE LEVELS OF NEUROPEPTIDE-Y MESSENGER-RNA IN THE ARCUATE NUCLEUS OF MICE
YOUNG, JK
MCKENZIE, JC
BRADY, LS
HERKENHAM, M
NEUROSCIENCE LETTERS, 1994, 165 (1-2) : 13 - 17
[38] EFFECT OF SUSTAINED PHYSIOLOGICAL HYPERINSULINEMIA ON HYPOTHALAMIC NEUROPEPTIDE-Y AND NPY MESSENGER-RNA LEVELS IN THE RAT
CUSIN, I
DRYDEN, S
WANG, Q
ROHNERJEANRENAUD, F
JEANRENAUD, B
WILLIAMS, G
JOURNAL OF NEUROENDOCRINOLOGY, 1995, 7 (03) : 193 - 197
[39] DETECTION OF NEUROPEPTIDE-Y AND ITS MESSENGER-RNA IN MEGAKARYOCYTES - ENHANCED LEVELS IN CERTAIN AUTOIMMUNE MICE
ERICSSON, A
SCHALLING, M
MCINTYRE, KR
LUNDBERG, JM
LARHAMMAR, D
SEROOGY, K
HOKFELT, T
PERSSON, H
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (16) : 5585 - 5589
[40] QUANTITATIVE STUDY OF TYROSINE-HYDROXYLASE PROTEIN-LEVELS WITHIN THE SOMATIC AREA OF THE RAT LOCUS-COERULEUS DURING POSTNATAL-DEVELOPMENT
BEZIN, L
MARCEL, D
ROUSSET, C
PUJOL, JF
WEISSMANN, D
JOURNAL OF NEUROSCIENCE, 1994, 14 (12): : 7502 - 7510

← 1 2 3 4 5 →