4-METHYLTRITYL (MTT) - A NEW PROTECTING GROUP FOR THE SIDE-CHAIN PROTECTION OF ASN AND GLN IN SOLID-PHASE PEPTIDE-SYNTHESIS

被引：0
|
作者：
SAX, B
DICK, F
TANNER, R
GOSTELI, J
机构：
来源：
PEPTIDE RESEARCH | 1992年 / 5卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The trityl group was recently introduced for the protection of the side chain carboxamide function of asparagine and glutamine. The 4-methyltrityl (Mtt) group, a structural modification of trityl, is presented here and allows more rapid cleavage from the protected peptides. Procedures for the introduction of the group and comparative cleavage reactions are also presented.
引用
下载
收藏
页码：245 / 246
页数：2
相关论文
共 50 条
  • [21] A FACILE METHOD FOR THE SIDE-CHAIN PROTECTION OF ALPHA-METHYL-BETA-3,4-DIHYDROXYPHENYL-L-ALANINE (ALPHA-MEDOPA) FOR SOLID-PHASE PEPTIDE-SYNTHESIS
    HSIEH, KH
    DEMAINE, MM
    SYNTHESIS-STUTTGART, 1991, (01): : 59 - 62
  • [22] SIDE REACTIONS IN PEPTIDE-SYNTHESIS .3. INTERMOLECULAR ACYLATION BY AN UNPROTECTED SIDE-CHAIN CARBOXYL GROUP
    NATARAJAN, S
    BODANSZKY, M
    JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (07): : 1269 - 1272
  • [23] A new strategy for synthesis of branched cyclic peptide by Asn side-chain hydrazide ligation
    Jian Lu
    Xiao-Bo Tian
    Wei Huang
    Chinese Chemical Letters, 2015, 26 (08) : 946 - 950
  • [24] A new strategy for synthesis of branched cyclic peptide by Asn side-chain hydrazide ligation
    Lu, Jian
    Tian, Xiao-Bo
    Huang, Wei
    CHINESE CHEMICAL LETTERS, 2015, 26 (08) : 946 - 950
  • [25] Water-Based Solid-Phase Peptide Synthesis without Hydroxy Side Chain Protection
    Hojo, Keiko
    Manabe, Yuki
    Uda, Tomoyo
    Tsuda, Yuko
    JOURNAL OF ORGANIC CHEMISTRY, 2022, 87 (17): : 11362 - 11368
  • [26] APPLICATION OF ACETAMIDOMETHYL AND 9-FLUORENYLMETHYL GROUPS FOR EFFICIENT SIDE PROTECTION OF PENICILLAMINE IN SOLID-PHASE PEPTIDE-SYNTHESIS
    GARCIAECHEVERRIA, C
    MOLINS, MA
    ALBERICIO, F
    PONS, M
    GIRALT, E
    INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1990, 35 (05): : 434 - 440
  • [27] PROTECTION OF ASPARTIC-ACID, SERINE, AND THREONINE IN SOLID-PHASE PEPTIDE-SYNTHESIS
    YAMASHIRO, D
    JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (03): : 523 - 525
  • [28] Side-chain anchoring strategy for solid-phase synthesis of peptide acids with C-terminal cysteine
    Barany, G
    Han, YX
    Hargittai, B
    Liu, RQ
    Varkey, JT
    BIOPOLYMERS, 2003, 71 (06) : 652 - 666
  • [29] The solid-phase synthesis of side-chain-phosphorylated peptide-4-nitroanilides
    Bernhardt, A
    Drewello, M
    Schutkowski, M
    JOURNAL OF PEPTIDE RESEARCH, 1997, 50 (02): : 143 - 152
  • [30] A NEW BASE-LABILE LINKER FOR SOLID-PHASE PEPTIDE-SYNTHESIS
    KATTI, SB
    MISRA, PK
    HAQ, W
    MATHUR, KB
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (11) : 843 - 844
12345