STUDIES ON SYNTHESIS, CHARACTERIZATION AND ANTITUMOR-ACTIVITY OF TERNARY COMPLEXES OF PYRUVIC-ACID ISONICOTINOYL HYDRAZONE AND 5-FLUOROURACIL-1-ACETIC ACID WITH RARE-EARTHS

被引：0
|
作者：
YANG, ZY [1 ]
YANG, RD [1 ]
WANG, LF [1 ]
YANG, XP [1 ]
机构：
[1] LANZHOU UNIV,DEPT CHEM,LANZHOU 730000,PEOPLES R CHINA
来源：
BULLETIN DES SOCIETES CHIMIQUES BELGES | 1995年 / 104卷 / 03期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Thirteen ternary complexes of pyruvic acid isonicotinoyl hydrazone(H2PPFH) and 5-fluorouracil-1-acetic (HFAA) with rare earths have been synthesized in the paper. The structure and properties of the ternary complexes were determined by elemental analyses, infrared and ultraviolet spectra, molar conductivity and H-1 NMR. A general formula of the complexes is RE(PPFH)(FAA)2H2O (RE(III) = La-Yb). Antitumor activity of La(PPFH) (FAA).2H2O was tested with Leukaemia cells L1210and transplanted mouse tumor colon cancer C27. The results show that the inhibitory rate for C27 is 41.2%.
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页码：129 / 135
页数：7
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