PYRIMIDINE-DERIVATIVES .8. ONE-STEP SYNTHESIS OF 3,4-DIHYDRO-PYRIMIDO[6,1-C][1,4]OXAZINE DERIVATIVES BY REACTIONS OF 5-BROMO-1-(2-BROMOETHYL)-6-BROMOMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE WITH SODIUM ALKOXIDES AND 2-NITROPROPANE

被引：4

作者：

KINOSHITA, T

UGA, M

TANIMOTO, Y

OHISHI, K

FURUKAWA, S

机构：

[1] School of Pharmaceutical Sciences, Nagasaki University, Nagasaki 852

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 10期

关键词：

TRIBROMO-PYRIMIDINE; SODIUM ALKOXIDE; 2-NITROPROPANE; RING FORMATION; PYRIMIDO[6,1-C][1,4]OXAZINE; OXIDATION; PYRIDINIUM DICHROMATE; 5-BROMO-1-(2-BROMOETHYL)-6-BROMOMETHYL-3-METHYL-2,4(1H,3H)-PYRIMIDINEDIONE;

D O I：

10.1248/cpb.40.2668

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reaction of 5-bromo-1-(2-bromoethyl)-6-bromomethyl-3-methyl-2,4(1H,3H)-pyrimidinedione (1) with the sodium alkoxide/2-nitropropane system and that of the dinitrate (2) of 5-bromo-1-(2-hydroxyethyl)-6-hydroxymethyl-3-methyl-2,4(1H,3H)-pyrimidinedione with sodium alkoxide provide convenient routes to a wide range of 3,4-dihydro-pyrimido[6,1-e][1,4]oxazine derivatives (3) in excellent yields.

引用

页码：2668 / 2670

页数：3

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