SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NOVEL 2-(BENZO[D][1,3]DIOXOL-5-YL)-6,7-DIMETHOXYLQUINAZOLIN-4(3H)-ONES

In view of generatingnew compounds for future drug development, we have synthesized some 2-(benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxylquinazolin-4(3H)-one derivatives of 4,5-dimethoxy-2-nitrobenzamide (5), synthesized by the ortho-nitro acid 4 was converted to its acid chloride by using thionyl chloride, followed by treatment with ammonia (aq.) gave the substituted ortho-nitro benzanilide (5). 4,5-Dimethoxy-2-nitrobenzamide (5) react withbenzo(d)[1,3] dioxole-5-carbaldehyde (6a) in presence of SnCl2 center dot 2H(2)O in MeOH was heated to gave 2-(benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxylquinazolin-4(3H)-ones (7a-k). All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and were evaluated for their antimicrobial activities in two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtillis) and two Gram-negative bacteria (Echerichia coli and Pseudomonas aeuroginosa) and two fungi (Aspergillusniger and Aspergillusfumigatus) strains using Cup plate method