COMPARISON OF A ONCE DAILY LONG-ACTING FORMULATION OF PROPRANOLOL WITH CONVENTIONAL PROPRANOLOL GIVEN TWICE DAILY IN PATIENTS WITH MILD TO MODERATE HYPERTENSION

The effect of conventional propranolol tablets given twice daily was compared with an equivalent dosage of a long-acting formulation of propranolol (Inderal LA)p given once daily in 29 patients with mild to moderate hypertension. The study lasted 10 wk. There was no significant difference in clinical response to the 2 treatments which were equally effective and well tolerated. A once daily dosage schedule should greatly aid patient compliance.