DOSIMETRY OF I-123 IOMAZENIL IN HUMANS

被引：11
|
作者：
VERHOEFF, NPLG
SOKOLE, EB
HENGST, D
STUBBS, JB
VANROYEN, EA
机构：
[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT RADIAT SAFETY,1105 AZ AMSTERDAM,NETHERLANDS
[2] OAK RIDGE INST SCI & EDUC,OAK RIDGE,TN
来源：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1993年 / 20卷 / 07期
关键词：
DOSIMETRY; I-123; RECEPTORS; BENZODIAZEPINE; FLUMAZENIL; IOMAZENIL;
D O I：
10.1007/BF00176551
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of I-123-IBZM for adults was estimated to be 0.033 mSv/MBq.
引用
收藏
页码：580 / 584
页数：5
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