DECREASED PLATELET SEROTONIN UPTAKE IN BIPOLAR-I PATIENTS

被引：16

作者：

MARAZZITI, D ^{[1
]}

LENZI, A ^{[1
]}

GALLI, L ^{[1
]}

SANMARTINO, S ^{[1
]}

CASSANO, GB ^{[1
]}

机构：

[1] UNIV PISA, CHAIR PSYCHIAT 2, I-56100 PISA, ITALY

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1991年 / 6卷 / 01期

关键词：

D O I：

10.1097/00004850-199100610-00004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The 5HT transporter complex in platelets is similar to that in the brain and thus widely used in biological psychiatry as a peripheral marker of the 5HT system. Our study aim was to measure C-14-5HT uptake parameters (Vmax and Km) in platelets from 12 patients affected by bipolar disorder, as compared with 12 healthy controls. The uptake assay was performed according to the method of Arora and Meltzer (1981). The results showed that the Vmax was significantly lower in bipolar patients than in healthy controls, with no modification of the Km. These preliminary data would indicate therefore that the mechanism of 5HT transport is altered in platelets of bipolar patients.

引用

页码：25 / 30

页数：6

共 50 条

[41] DEPRESSED-PATIENTS - PLATELET HA CONTENT AND HA MODULATION OF PLATELET SEROTONIN UPTAKE
LEPINE, JP
LAUNAY, JM
SOLIMAN, HR
BONDOUX, D
DREUX, C
ROUILLON, F
LEMPERIERE, TH
INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1987, 32 (1-2) : 308 - 309
[42] Further evidence for robust familiality of pediatric bipolar-I disorder
Biederman, J.
BIPOLAR DISORDERS, 2013, 15 : 63 - 64
[43] CLINICAL-EVIDENCE FOR GENOMIC IMPRINTING IN BIPOLAR-I DISORDER
GRIGOROIUSERBANESCU, M
NOTHEN, M
PROPPING, P
POUSTKA, F
MAGUREANU, S
VASILESCU, R
MARINESCU, E
ARDELEAN, V
ACTA PSYCHIATRICA SCANDINAVICA, 1995, 92 (05) : 365 - 370
[44] INDICATIONS OF GENETIC-HETEROGENEITY IN 68 BIPOLAR-I PROBAND FAMILIES
GO, RC
ELSTON, RC
FIEVE, RR
DUNNER, DD
BARRETT, C
AMERICAN JOURNAL OF HUMAN GENETICS, 1980, 32 (06) : A143 - A143
[45] PLATELET SEROTONIN UPTAKE AND EFFLUX IN MIGRAINE
MONSTAD, P
LINGJAERDE, O
ACTA NEUROLOGICA SCANDINAVICA, 1984, 69 : 273 - 274
[46] Effect of cannabinoids on platelet serotonin uptake
Velenovska, Marie
Fisar, Zdenek
ADDICTION BIOLOGY, 2007, 12 (02) : 158 - 166
[47] PLATELET SEROTONIN UPTAKE IN PANIC DISORDER
NORMAN, TR
JUDD, FK
GREGORY, M
JAMES, RH
KIMBER, NM
MCINTYRE, IM
BURROWS, GD
JOURNAL OF AFFECTIVE DISORDERS, 1986, 11 (01) : 69 - 72
[48] PHYSOSTIGMINE EFFECT ON PLATELET SEROTONIN UPTAKE
RAUSCH, J
JANOWSKY, D
RISCH, S
HUEY, L
SWANSON, G
ADVANCES IN BIOCHEMICAL PSYCHOPHARMACOLOGY, 1982, 34 : 326 - 327
[49] Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients
Mellerup, E
Bennike, B
Bolwig, T
Dam, H
Hasholt, L
Jorgensen, MB
Plenge, P
Sorensen, SA
ACTA PSYCHIATRICA SCANDINAVICA, 2001, 103 (03) : 229 - 233
[50] PLATELET IMIPRAMINE BINDING AND SEROTONIN UPTAKE IN OBSESSIVE-COMPULSIVE PATIENTS
VITIELLO, B
SHIMON, H
BEHAR, D
STOFF, D
BRIDGER, WH
FRIEDMAN, E
ACTA PSYCHIATRICA SCANDINAVICA, 1991, 84 (01) : 29 - 32

← 1 2 3 4 5 →