DECREASED PLATELET SEROTONIN UPTAKE IN BIPOLAR-I PATIENTS

被引：16

作者：

MARAZZITI, D ^{[1
]}

LENZI, A ^{[1
]}

GALLI, L ^{[1
]}

SANMARTINO, S ^{[1
]}

CASSANO, GB ^{[1
]}

机构：

[1] UNIV PISA, CHAIR PSYCHIAT 2, I-56100 PISA, ITALY

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1991年 / 6卷 / 01期

关键词：

D O I：

10.1097/00004850-199100610-00004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The 5HT transporter complex in platelets is similar to that in the brain and thus widely used in biological psychiatry as a peripheral marker of the 5HT system. Our study aim was to measure C-14-5HT uptake parameters (Vmax and Km) in platelets from 12 patients affected by bipolar disorder, as compared with 12 healthy controls. The uptake assay was performed according to the method of Arora and Meltzer (1981). The results showed that the Vmax was significantly lower in bipolar patients than in healthy controls, with no modification of the Km. These preliminary data would indicate therefore that the mechanism of 5HT transport is altered in platelets of bipolar patients.

引用

页码：25 / 30

页数：6

共 50 条

[21] Learning from positive and negative feedback in patients with bipolar-I disorder and their relatives
Scholz, V.
Linke, J.
Kollmann, B.
Wessa, M.
BIPOLAR DISORDERS, 2015, 17 : 71 - 71
[22] Comorbidity of anxiety disorders in patient with bipolar-I disorder
Tamam, L
Ozpoyraz, N
EUROPEAN PSYCHIATRY, 2000, 15 : 353S - 353S
[23] Antidepressant-associated maniform states in acute treatment of patients with bipolar-I depression
Bottlender, R
Rudolf, D
Strauss, A
Möller, HJ
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 1998, 248 (06) : 296 - 300
[24] Transcranial Photobiomodulation to Augment Lithium in Bipolar-I Disorder
Mannu, Piero
Saccaro, Luigi F.
Spera, Vincenza
Cassano, Paolo
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY, 2019, 37 (10) : 577 - 578
[25] The effect of lamotrigine on platelet serotonin concentration in patients with bipolar depression
Marina Sagud
Nela Pivac
Maja Mustapic
Gordana Nedic
Alma Mihaljevic Peles
Milivoj Kramaric
Miro Jakovljevic
Dorotea Muck-Seler
Psychopharmacology, 2008, 197 : 683 - 685
[26] The effect of lamotrigine on platelet serotonin concentration in patients with bipolar depression
Sagud, Marina
Pivac, Nela
Mustapic, Maja
Nedic, Gordana
Peles, Alma Mihaljevic
Kramaric, Milivoj
Jakovljevic, Miro
Muck-Seler, Dorotea
PSYCHOPHARMACOLOGY, 2008, 197 (04) : 683 - 685
[27] Platelet uptake of GABA and glutamate in patients with bipolar disorder
Daniele, Simona
Da Pozzo, Eleonora
Abelli, Marianna
Panighini, Anna
Pini, Stefano
Gesi, Camilla
Lari, Lisa
Cardini, Alessandra
Cassano, Giovanni Battista
Martini, Claudia
BIPOLAR DISORDERS, 2012, 14 (03) : 301 - 308
[28] Episode cycles with increasing recurrences in first-episode bipolar-I disorder patients
Baldessarini, R. J.
Salvatore, P.
Khalsa, H. -M. K.
Imaz-Etxeberria, H.
Gonzalez-Pinto, A.
Tohen, M.
JOURNAL OF AFFECTIVE DISORDERS, 2012, 136 (1-2) : 149 - 154
[29] PLATELET SEROTONIN UPTAKE AND MIGRAINE
LAUNAY, JM
PRADALIER, A
DREUX, C
DRY, J
CEPHALALGIA, 1982, 2 (02) : 57 - 59
[30] Antidepressant-associated maniform states in acute treatment of patients with bipolar-I depression
R. Bottlender
Daniel Rudolf
Anton Strauss
Hans-Jürgen Möller
European Archives of Psychiatry and Clinical Neuroscience, 1998, 248 : 296 - 300

← 1 2 3 4 5 →