YM-14673, A NEW THYROTROPIN-RELEASING-HORMONE ANALOG, AUGMENTS LONG-TERM POTENTIATION IN THE MOSSY FIBER-CA3 SYSTEM OF GUINEA-PIG HIPPOCAMPAL SLICES

被引：6

作者：

ISHIHARA, K ^{[1
]}

KATSUKI, H ^{[1
]}

SUGIMURA, M ^{[1
]}

SATOH, M ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,YOSHIDA SHIMOADACHI CHO,SAKYO KU,KYOTO 60601,JAPAN

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1992年 / 15卷 / 02期

关键词：

YM-14673 (TRH-ANALOG); THYROTROPIN-RELEASING HORMONE (TRH); LONG-TERM POTENTIATION; GUINEA PIG; HIPPOCAMPAL SLICE; MOSSY FIBER; CA3;

D O I：

10.1248/bpb1978.15.75

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effects of a new thyrotropin-releasing hormone (TRH) analog, N(alpha)-[[(S)-4-oxo-2-azetidinyl]carbonyl]L-histidyl-L-prolinamide dihydrate (YM-14673), which improves experimentally induced memory dysfunction, on long-term potentiation (LTP) in the mossy fiber-CA3 system, were investigated using guinea pig hippocampal slices. At concentrations of 10(-7) M and 10(-6) M, YM-14673 significantly augmented LTP in a concentration dependent manner. The magnitude of effect of 10(-6) M YM-14673 was similar to that of 10(-6) M TRH. As LTP in the hippocampus is regarded as an elementary process of memory and learning, the augmenting effect of YM-14673 on LTP in the present study may contribute to this drug's ability to remedy memory dysfunction.

引用

页码：75 / 78

页数：4

共 33 条

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