YM-14673, A NEW THYROTROPIN-RELEASING-HORMONE ANALOG, AUGMENTS LONG-TERM POTENTIATION IN THE MOSSY FIBER-CA3 SYSTEM OF GUINEA-PIG HIPPOCAMPAL SLICES

被引：6

作者：

ISHIHARA, K ^{[1
]}

KATSUKI, H ^{[1
]}

SUGIMURA, M ^{[1
]}

SATOH, M ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,YOSHIDA SHIMOADACHI CHO,SAKYO KU,KYOTO 60601,JAPAN

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1992年 / 15卷 / 02期

关键词：

YM-14673 (TRH-ANALOG); THYROTROPIN-RELEASING HORMONE (TRH); LONG-TERM POTENTIATION; GUINEA PIG; HIPPOCAMPAL SLICE; MOSSY FIBER; CA3;

D O I：

10.1248/bpb1978.15.75

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effects of a new thyrotropin-releasing hormone (TRH) analog, N(alpha)-[[(S)-4-oxo-2-azetidinyl]carbonyl]L-histidyl-L-prolinamide dihydrate (YM-14673), which improves experimentally induced memory dysfunction, on long-term potentiation (LTP) in the mossy fiber-CA3 system, were investigated using guinea pig hippocampal slices. At concentrations of 10(-7) M and 10(-6) M, YM-14673 significantly augmented LTP in a concentration dependent manner. The magnitude of effect of 10(-6) M YM-14673 was similar to that of 10(-6) M TRH. As LTP in the hippocampus is regarded as an elementary process of memory and learning, the augmenting effect of YM-14673 on LTP in the present study may contribute to this drug's ability to remedy memory dysfunction.

引用

页码：75 / 78

页数：4

共 33 条

[11] BENEFICIAL EFFECT OF THE NONSELECTIVE OPIATE ANTAGONIST NALOXONE HYDROCHLORIDE AND THE THYROTROPIN-RELEASING-HORMONE (TRH) ANALOG YM-14673 ON LONG-TERM NEUROBEHAVIORAL OUTCOME FOLLOWING EXPERIMENTAL BRAIN INJURY IN THE RAT
MCINTOSH, TK
FERNYAK, S
HAYES, RL
FADEN, AI
JOURNAL OF NEUROTRAUMA, 1993, 10 (04) : 373 - 384
[12] INHIBITORY INFLUENCE VIA 5-HT3 RECEPTORS ON THE INDUCTION OF LTP IN MOSSY FIBER-CA3 SYSTEM OF GUINEA-PIG HIPPOCAMPAL SLICES
MAEDA, T
KANEKO, S
SATOH, M
NEUROSCIENCE RESEARCH, 1994, 18 (04) : 277 - 282
[13] Late Phase of Long-Term Potentiation in the Mossy Fiber-CA3 Hippocampal Pathway Is Critically Dependent on Metalloproteinases Activity
Wojtowicz, Tomasz
Mozrzymas, Jerzy W.
HIPPOCAMPUS, 2010, 20 (08) : 917 - 921
[14] BENZODIAZEPINE INVERSE AGONISTS AUGMENT LONG-TERM POTENTIATION IN CA1 AND CA3 OF GUINEA-PIG HIPPOCAMPAL SLICES
YASUI, M
KAWASAKI, K
MATSUSHITA, A
SATOH, M
NEUROPHARMACOLOGY, 1993, 32 (02) : 127 - 131
[15] TEA-induced long-term potentiation at hippocampal mossy fiber-CA3 synapses: Characteristics of its induction and expression
Suzuki, Etsuko
Okada, Takashi
BRAIN RESEARCH, 2009, 1247 : 21 - 27
[16] The involvement of Group I mGluR in tetraethylammonium-induced long-term potentiation at hippocampal mossy fiber-CA3 synapses
Suzuki, Etsuko
Okada, Takashi
NEUROSCIENCE RESEARCH, 2010, 68 : E341 - E341
[17] Endogenous Zn2+ is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses
Lu, YM
Taverna, FA
Tu, R
Ackerley, CA
Wang, YT
Roder, J
SYNAPSE, 2000, 38 (02) : 187 - 197
[18] REQUIREMENT OF EXTRACELLULAR CA-2+ AFTER TETANUS FOR INDUCTION OF LONG-TERM POTENTIATION IN GUINEA-PIG HIPPOCAMPAL SLICES
IZUMI, Y
ITO, K
MIYAKAWA, H
KATO, H
NEUROSCIENCE LETTERS, 1987, 77 (02) : 176 - 180
[19] Galanin inhibits long-term potentiation at Schaffer collateral-CA1 synapses in guinea-pig hippocampal slices
Sakurai, E
Maeda, T
Kaneko, S
Akaike, A
Satoh, M
NEUROSCIENCE LETTERS, 1996, 212 (01) : 21 - 24
[20] Time-dependent reversal of long-term potentiation by low-frequency stimulation at the hippocampal mossy fiber-CA3 synapses
Chen, YL
Huang, CC
Hsu, KS
JOURNAL OF NEUROSCIENCE, 2001, 21 (11): : 3705 - 3714

← 1 2 3 4 →