AMPLIFICATION OF CYCLIN GENES IN COLORECTAL CARCINOMAS

被引：0
|
作者：
LEACH, FS
ELLEDGE, SJ
SHERR, CJ
WILLSON, JKV
MARKOWITZ, S
KINZLER, KW
VOGELSTEIN, B
机构：
[1] JOHNS HOPKINS UNIV, SCH MED, DEPT ONCOL, BALTIMORE, MD 21231 USA
[2] BAYLOR COLL MED, DEPT BIOCHEM, HOUSTON, TX 77030 USA
[3] ST JUDE CHILDRENS RES HOSP, DEPT TUMOR CELL BIOL, MEMPHIS, TN 38101 USA
[4] CASE WESTERN RESERVE UNIV, UNIV HOSP CLEVELAND, DEPT MED, IRELAND CANC CTR, CLEVELAND, OH 44106 USA
来源：
CANCER RESEARCH | 1993年 / 53卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin D1, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms.
引用
收藏
页码：1986 / 1989
页数：4
相关论文
共 50 条
  • [41] RADIOTHERAPY OF COLORECTAL CARCINOMAS
    SCHERTEL, L
    SCHNEPPER, E
    LANGENBECKS ARCHIV FUR CHIRURGIE, 1979, 348 (02): : 133 - 139
  • [42] The colorectal carcinomas and their immunophenotypes
    Gurzu, S.
    Jung, I
    VIRCHOWS ARCHIV, 2009, 455 : 205 - 205
  • [43] The relationship between microsatellite instability and cancer-associated genes in sporadic colorectal carcinomas
    Shitoh, K
    Konishi, F
    Miyaki, M
    Iijima, T
    Tsukamoto, T
    Masubuchi, S
    Kanazawa, K
    GASTROENTEROLOGY, 1999, 116 (04) : A504 - A504
  • [44] Semi-quantitative procedure for telomeric repeat amplification protocol (TRAP) assay in colorectal carcinomas.
    Fujita, M
    Tomita, S
    Nakamura, T
    Kashiwagi, R
    Tabata, F
    Ueda, Y
    Fujimori, T
    GASTROENTEROLOGY, 1999, 116 (04) : A408 - A408
  • [45] One Step Nucleic Acid Amplification (OSNA) - a new method for lymph node staging in colorectal carcinomas
    Roland S Croner
    Vera Schellerer
    Helene Demund
    Claus Schildberg
    Thomas Papadopulos
    Elisabeth Naschberger
    Michael Stürzl
    Klaus E Matzel
    Werner Hohenberger
    Anne Schlabrakowski
    Journal of Translational Medicine, 8
  • [46] One Step Nucleic Acid Amplification (OSNA) - a new method for lymph node staging in colorectal carcinomas
    Croner, Roland S.
    Schellerer, Vera
    Demund, Helene
    Schildberg, Claus
    Papadopulos, Thomas
    Naschberger, Elisabeth
    Stuerzl, Michael
    Matzel, Klaus E.
    Hohenberger, Werner
    Schlabrakowski, Anne
    JOURNAL OF TRANSLATIONAL MEDICINE, 2010, 8
  • [47] Cyclin E overexpression in human gallbladder carcinomas
    Eguchi, N
    Fujii, K
    Tsuchida, A
    Yamamoto, S
    Sasaki, T
    Kajiyama, G
    ONCOLOGY REPORTS, 1999, 6 (01) : 93 - 96
  • [48] Cyclin D1 in thyroid carcinomas
    Shi, Y
    Zou, M
    Varkondi, E
    Nagy, A
    Kozma, L
    Farid, NR
    THYROID, 2001, 11 (07) : 709 - 710
  • [49] Expression and amplification of cyclin D1 in primary breast carcinomas: Relationship with histopathological types and clinico-pathological parameters
    Naidu, R
    Wahab, NA
    Yadav, MM
    Kutty, MK
    ONCOLOGY REPORTS, 2002, 9 (02) : 409 - 416
  • [50] Amplification of Thymosin Beta 10 and AKAP13 Genes in Metastatic and Aggressive Papillary Thyroid Carcinomas
    Feher, Liliaa Z.
    Pocsay, Gobor
    Krenacs, Laszlo
    Zvara, Agnes
    Bagdi, Eniko
    Pocsay, Reka
    Lukacs, Geza
    Gyory, Ferenc
    Gazdag, Andrea
    Tarko, Erzsebet
    Puskas, Laszlo G.
    PATHOLOGY & ONCOLOGY RESEARCH, 2012, 18 (02) : 449 - 458
12345