AMPLIFICATION OF CYCLIN GENES IN COLORECTAL CARCINOMAS

被引：0

作者：

LEACH, FS

ELLEDGE, SJ

SHERR, CJ

WILLSON, JKV

MARKOWITZ, S

KINZLER, KW

VOGELSTEIN, B

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT ONCOL, BALTIMORE, MD 21231 USA

[2] BAYLOR COLL MED, DEPT BIOCHEM, HOUSTON, TX 77030 USA

[3] ST JUDE CHILDRENS RES HOSP, DEPT TUMOR CELL BIOL, MEMPHIS, TN 38101 USA

[4] CASE WESTERN RESERVE UNIV, UNIV HOSP CLEVELAND, DEPT MED, IRELAND CANC CTR, CLEVELAND, OH 44106 USA

来源：

CANCER RESEARCH | 1993年 / 53卷 / 09期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin D1, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms.

引用

页码：1986 / 1989

页数：4

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