AN IMPROVED REACTION OF TRIS(METHYLTHIO)METHANE WITH EPOXIDES - APPLICATION TO THE EFFICIENT SYNTHESIS OF BETA-HYDROXY ESTERS

被引：8

作者：

ABOOD, NA

机构：

[1] Department of Chemistry, Searle Research and Development, Skokie, Illinois

来源：

SYNTHETIC COMMUNICATIONS | 1993年 / 23卷 / 06期

关键词：

D O I：

10.1080/00397919308009842

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tris(methylthio)methyllithium reacts efficiently with epoxides in THF:HMPA (5:1) at low temperature to give beta-hydroxy orthotrithiocarboxylates which are converted to beta-hydroxy esters in high yield.

引用

页码：811 / 815

页数：5

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