UTERINE ATROPHY IN CHRONIC MURINE TOXOPLASMOSIS DUE TO OVARIAN DYSFUNCTION

被引：14
|
作者：
STAHL, W
KANEDA, Y
TANABE, M
KUMAR, SA
机构：
[1] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,ALBANY,NY 12201
[2] KEIO UNIV,SCH MED,DEPT TROP MED & PARASITOL,TOKYO 160,JAPAN
来源：
PARASITOLOGY RESEARCH | 1995年 / 81卷 / 02期
关键词：
D O I：
10.1007/BF00931614
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Uterine atrophy is a conspicuous finding in Nya:NYLAR female mice chronically infected with Toxoplasma gondii. Administration of 17B-estradiol to infected mice induced a vigorous uterotropic response, i.e., an increase in uterine weight, in endometrial hypertrophy and proliferation, and in the activity of three estrogen-regulated uterine enzymes. These findings rule out a parasite-induced refractoriness of the uterus to estrogen and point to ovarian dysfunction (hypogonadism) as the immediate cause of the uterine atrophy.
引用
收藏
页码：109 / 113
页数：5
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