UTERINE ATROPHY IN CHRONIC MURINE TOXOPLASMOSIS DUE TO OVARIAN DYSFUNCTION

被引：14

作者：

STAHL, W

KANEDA, Y

TANABE, M

KUMAR, SA

机构：

[1] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,ALBANY,NY 12201

[2] KEIO UNIV,SCH MED,DEPT TROP MED & PARASITOL,TOKYO 160,JAPAN

来源：

PARASITOLOGY RESEARCH | 1995年 / 81卷 / 02期

关键词：

D O I：

10.1007/BF00931614

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Uterine atrophy is a conspicuous finding in Nya:NYLAR female mice chronically infected with Toxoplasma gondii. Administration of 17B-estradiol to infected mice induced a vigorous uterotropic response, i.e., an increase in uterine weight, in endometrial hypertrophy and proliferation, and in the activity of three estrogen-regulated uterine enzymes. These findings rule out a parasite-induced refractoriness of the uterus to estrogen and point to ovarian dysfunction (hypogonadism) as the immediate cause of the uterine atrophy.

引用

页码：109 / 113

页数：5

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